"The Joy of Why" is a Quanta Magazine podcast about curiosity and the pursuit of knowledge. The mathematician and author Steven Strogatz and the astrophysicist and author Janna Levin take turns interviewing leading researchers about the great scientific and mathematical questions of our time. New episodes are released every other Thursday.

Scientists routinely build quantitative models — of, say, the weather or an epidemic — and then use them to make predictions, which they can then test against the real thing. This work can reveal how well we understand complex phenomena, and also dictate where research should go next. In recent years, the remarkable successes of “black box” systems such as large language models suggest that it is sometimes possible to make successful predictions without knowing how something works at all. In this episode, noted statistician Emmanuel Candès and host Steven Strogatz discuss using statistics, data science and AI in the study of everything from college admissions to election forecasting to drug discovery.

The Joy of Why

How Is AI Changing the Science of Prediction?

The “species” category is almost certainly the best known of all the taxonomic classifications that biologists use to organize life’s vast diversity. It’s a linchpin of both conservation policy and evolutionary theory, though in practice biologists have struggled to find a definition that works across the natural world. In this episode, Kevin de Queiroz, a zoologist and evolutionary biologist, talks with host Janna Levin about the variety of ways to conceive of a species, and ways to understand the relationships among living things.

When we think about medicine’s war on cancer, treatments such as surgery, radiation and chemotherapy spring to mind first. Now there is another potential weapon for defeating tumors: statistics and mathematical models that can optimize the selection, combination or timing of treatment. Building and feeding these models requires accounting for the complexity of the body, and recognizing that cancer cells are constantly evolving. In this episode, host Steven Strogatz hears from Franziska Michor, a computational biologist, about how our understanding of evolutionary dynamics is being used to devise new anticancer therapies.

How Can Math Help Beat Cancer?

If instruments do someday detect evidence of life beyond Earth, whether it’s in this solar system or in the farther reaches of space, astrobiologists want to be ready. One of the best ways to learn how alien life might function can be to study the organisms called extremophiles, which live in incredibly challenging environments on or in the Earth. In this episode, <a href="https://astrobiology.nasa.gov/nai/directory/boston-penelope/">Penelope Boston</a>, a microbiologist who has worked for many years with NASA, speaks with <a href="https://barnard.edu/profiles/janna-levin">Janna Levin</a> about the bizarre life found in habitats such as caves, how it would be possible to detect life beyond our solar system and what it would mean for humanity if we do.

Steven Strogatz, Janna Levin, and Quanta Magazine

The Joy of Why by Steven Strogatz, Janna Levin, and Quanta Magazine

Episodes